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Home » Comune di Roma, Primo piano

5th Mutant p53 Workshop ad Ariccia

Scritto da on martedì, 24 maggio 2011No Comment

E’ la prima volta che questo congresso si svolge in Italia, delle 4 precedenti edizioni, 2 sono state organizzate in israele presso l’Istituto Weitzmann (uno dei più importanti centri di ricerca biomedica al mondo) e le altre due edizioni sono state organizzate a Lione dall’International Agency for Research on Cancer (World Health Organization). Grazie all’istituto Regina Elena e in particolare al direttore scientifico Paola Muti e al Coordinatore dei Laboratori Ire Dottor Giovanni Blandino, quest’anno il Workshop si è tenuto in Italia.
Guarda le interviste realizaate da Media Live

SUNDAY 22 MAY

13.00 Arrival and Registration
16.00 Welcome
Prof. Paola MUTI, IRE Scientific Director,
Dr. Emilio CIANFANELLI, Mayor of Ariccia

Chairperson: Wolfgang Deppert
16.30 Opening Lecture:
Pierre Hainaut “TP53 Mutations in 2011: A mutante, mutante e mezzo”
17.45 Welcome Cocktail
18.15 – 20.00 Guided Tour of Palazzo Chigi

MONDAY 23 MAY

SESSION 1: 08.30 -12.45 “Mutant p53 activities in vitro”
Chairpersons: Guillermina Lozano and Carol Prives

08.30-08.55 EMBO LECTURE
Varda Rotter
“The role of p53 in the induction of pluripotent stem cells”

09.00-09.25 Thanos Halazonetis
“Structural properties of p53 DNA binding and regulation of genomic instability in iPS cells by p53”

09.30-09.55 David Lane
“Control of the stability of Mutant p53 by Mdm2/MdmX”

10.00-10.12 Marianne Farnebo
“WRAP53, a natural p53 antisense transcript required for p53 basal expression and induction upon DNA damage”

10.15-10.27 Antonio Costanzo
“Interplay between IKKa and mutant p53 in regulation of sensitvity to TGFb at early stages of skin carcinogenesis”

10.30-10.42 Silvia Di Agostino
“Mutant p53 and Plk2 proteins are components of an oncogenic autoregulatory feedback loop”

10.45-11.15 COFFEE BREAK

11.15-11.40 Alan Fersht
“p53 search for response elements”

11.45-12.10 Zippora Shakked
“From wild-type to mutant p53 structure and back”

12.15-12.40 Micheal Resnick
The human TLR innate immune gene family is differentially influenced by wild type and mutant p53 across cancer lines

13.00 – Lunch

14.00-15.15 POSTER SESSION at the Hotel

SESSION 2: 15.30 -19.30 “Mutant p53 Transcriptomics”
Chairpersons: Moshe Oren and Maurizio Fanciulli

15.30-15.55 Giovanni Blandino
“Oncogenic Transcriptional activity of mutant p53”

16.00-16.25 Sumitra Deb
“Activation of gene expression by gain of function p53 mutants”

16.30-16.55 Xin Lu
“ASPPs: potential mediators of mutant p53”

17.00-17.25 Carol Prives
“Pathways utilized by mutant p53 to alter morphogenesis of breast cancer cells in 3D cultures”

17.30-18.00 COFFEE BREAK

18.00-18.25 Karen Vousden
“Functions of mutant p53 in cell scattering and invasion”

18.30-18.42 Giulia Fontemaggi
“The mp53/Id4 axis controls gene expression in breast cancer and tumor-associated stromal cells”

18.45-19.10 Giannino Del Sal
“A Pin1/mutant p53 axis promotes aggressiveness in breast cancer”

19.15-19.27 Shunbin Xiong
“Mining for Genes Involved in Metastasis in p53515A/+ (p53R172H/+)Mice”

20.30 DINNER AT THE HOTEL

22.00–23.00 POSTER SESSION at the Hotel

TUESDAY 24 MAY
SESSION 3: 08.30 -12.55 “Mutant p53 activities in vivo”
Chairpersons: Giovanni Blandino and Giannino Del Sal

08.30-08.55 Stefano Piccolo
“The p63 target Sharp1 opposes breast cancer metastasis by presenting Hypoxia-Inducible-Factors to the proteasome”

09.00-09.25 FONDAZIONE VERONESI LECTURE
Guillermina Lozano
“Mutant p53 gain-of-function activities in tumorigenesis”

09.30-09.55 Moshe Oren
“Mutant p53 promotes inflammation- associated cancer”

10.00-10.25 Wolfgang Deppert
“Mutant P53 GOF in a mouse model for oncogene-induced mammary carcinogenesis”

10.30-10.55 Ygal Haupt
“Regulation of the p53-PML tumour suppression circuit”

11.00-11.30 COFFEE BREAK

11.30-11.55 Hein Te Riele
“Differential reactivation potential of mutant p53”

12.00-12.12 Gianluca Bossi
“IL-1Ra a putative target gene through which mutant p53-R273H contributes to tumor microenvironment”

12.15-12.27 Kanaga Sabapathy
“Dominant-negative effect of mutant p53 is cell-type specific and dose-dependent, and affects acute p53-response but does not accentuate tumorigenesis”

12.30-12.55 Yuan Zhu
“The role of mutant p53 in neural stem cells and brain tumor development”

13.00 – Lunch

14.00-15.00 POSTER SESSION at the Hotel

SESSION 4: 15.00-19.30 “p53 mutations in human cancer”
Chairpersons:Varda Rotter and Eva Schernhammer

15.00-15.25 Curtis Harris
“p53, MicroRNAs and Senescence in Human Carcinogenesis”

15.30-15.55 David Malkin
“Finding a Role for Germline p53 Mutation Analysis in Clinical Practice”

16.00-16.25 Gerard Zambetti
“Biological and Translational Studies of p53 in Childhood Cancers”

16.30 -16.50 COFFEE BREAK

16.50-17.02 Elena Martynova
“Genome-wide analysis of mutant p53 DNA-binding in human keratinocytes”

17.05-17.17 Genrich V. Tolstonog
“Mutant p53: a transcriptional co-factor involved in generating transcriptional plasticity”

17.20-17.32 Hilla Solomon
“Various p53 mutant types differently regulate the Ras circuit to induce a cancer-related gene signature”

17.35-17.47 Ge Zhou
“Gain-Of-Function Mutant p53 Promotes Cell Growth and Anabolism Through Direct Inactivation of AMPK”

18.00-18.25 Anne-Lise Børrensen-Dale
“Pathway disruption analyses according to TP53 mutation status in breast cancer subtypes”

18.30-18.55 Magali Olivier
“Prognostic and predictive value of TP53 mutations in breast cancer: results from BIG 02-98 trial”

19.00-19.12 Jean-Christophe Bourdon
“Biological activities of mutant p53 isoforms”

19.15-19.27 Frederic Rosseau
“”Gain of function of mutant p53 by coaggregation with multiple tumor suppressors”

20.30 SOCIAL DINNER AT THE HOTEL
WEDNESDAY 25 MAY

SESSION 5: 9.30 -12.15 “Mutant p53 as a therapeutic target”
Sala Pietro da Cortona at the Musei Capitolini – Rome
Shuttle Buses from Ariccia at 7,45 AM

Chairpersons: Anne-Lise Børrensen-Dale and Pierre Hainaut

09.30-09.55 Klas Wiman
“Novel cancer therapy by targeting the p53 pathway”

10.00-10.25 Andrei Gudkov title to be announced

10.30-10.55 Galina Selivanova
“Is it possible to target simultaneously wild type and mutant p53?”

11.00-11.25 Ute Moll
“Pharmacological destabilization of mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis shows preferential cytotoxicity in mutant p53 cancer cells”

11.30-12.15 CLOSING LECTURE AND CONCLUDING REMARKS
Arnold Levine “Exploration of Synthetic Letha
l Compounds for Specific p53 Mutant Alleles”

13.00 Farewell Cocktail at Terrazza Caffarelli
located in the Musei Capitolini

15.00-16.30 Guided tour of the Musei Capitolini

5th Mutant p53 Workshop
“From bench to bedside across mouse models”

Palazzo Chigi, Ariccia (Rome)
22-25 May 2011

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